The reason and treatment method of the tableting machine: the sticking is the sticking of the fine powder on the surface of the tablet by the punch and the die, so that the sheet surface is not only uneven, the unevenness is dent, and the lettering punch is more likely to stick.
1. The surface of the punch is damaged or the surface finish is reduced. There may also be anti-rust oil or lubricating oil, the surface of the new die is rough or the lettering is too deep and angular. The punch can be wiped clean, replaced with a substandard die or rubbed with a trace of liquid paraffin on the surface of the lettering punch to lubricate the surface. In addition, if it is caused by mechanical heating, check the cause and repair the equipment.
2, engraved, rushed character design is not reasonable. Replace the punch or change the character design accordingly.
3. The moisture content of the particles is too much or the particles are not dry and wet, resulting in sticking. Solution: Control the particle moisture in the range of 2% ~ 3%, strengthen the dry grain inspection.
4, the amount of lubricant is insufficient or improper selection, too much fine powder. Appropriately increase the amount of lubricant or replace with a new lubricant to remove excess fines.
5. The difference in fineness of the original excipients is large, resulting in uneven mixing or improper mixing time. Solution: The raw and auxiliary materials are crushed and sieved to make the fineness meet the quality requirements of the variety, and the mixing time is mastered and controlled.
6. The adhesive concentration is low or the adhesion is poor due to the quality of the adhesive. The fine powder is too much (more than 10%) and sticks. Solution: The fine powder is sieved with a 40-mesh sieve, regranulated, dried, and granulated, and the whole batch is uniformly mixed and then tableted.
7. Sticking due to the raw material itself (such as hygroscopicity). Solution: Add a certain amount of absorbent (such as adding 3% calcium hydrogen phosphate) to avoid sticking.
8. The ambient humidity is too high and the humidity is too high. Reduce ambient humidity.
9, the operating room temperature is too high, easy to produce sticky punch. Care should be taken to reduce the operating room temperature.
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