High Quality 99% Purity CAS 147127-20-6 Tenofovir with Safety Shipping

Description

Tenofovir is indicated for the treatment of HIV, HBV infection. This product also can cooperated with other reverse transcriptase inhibitors for HIV-1 infection and hepatitis B treatment.

Pharmacokinetics

Tenofovir is hardly absorbed through the gastrointestinal tract, for this reason, prodrug of Tenofovir has been developed by esterification, and then to make tenofovir fumarate ester. Tenofovir ester is water-soluble, can be rapidly absorbed and degraded into the active tenofovir, and then was metabolized to the active Tenofovir disoproxil. Tenofovir will reach the peak of plasma Concentration within 1-2 h after administration. When combined with food service, the bioavailability of Tenofovir can be increased by 40%. Intracellular half-life of Tenofovir disoproxil is about 10 h, it needs dosing everyday. Because Tenofovir is not a CYP-450 substrate, this may decrease the possibility of interactions with other drugs caused by CYP450. Elimination of Tenofovir is by glomerular filtration and active tubular secretion. Approximately 70% to 80% is recovered in urine as unchanged drug. Elimination half-life is approximately 17 h.

Usage

Acyclic phosphonate nucleotide analogue. Used as an anti-HIV agent
Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.
Tenofovir blocks reverse transcriptase and hepatitis B virus infections.

Adverse effects

1.The most common side effects associated with Tenofovir include asthenia.
2.Tenofovir has also been implicated in mild to moderate gastrointestinal reactions such as nausea, vomiting, diarrhea, and asthenia. Less frequent side effects include hepatotoxicity, abdominal pain, and flatulence,bloating, lactic acidosis, hepatomegaly with fatty liver, pancreatitis and so on. these adverse effects are common with the use of nucleoside analogues either separately or when combined with other drugs.
3.Tenofovir can also lead to metabolic system hypophosphatemia (1% incidence); fat accumulation and redistribution, including central obesity, buffalo hump, peripheral wasting, breast enlargement, Cushing syndrome.
4.Tenofovir may cause lactic acidosis, hepatomegaly with steatosis-related and so on.
5.Tenofovir may make nervous system: dizziness, headache.
6.Tenofovir sometimes leads to respiratory system: dyspnea.
7.Tenofovir may cause skin herpes.



 

Product Packaging

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag),or as required.

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

Storage

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery

Usually within 3-7 working days after payment.

Shipping

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Service

we will try our best to satisfied you.
1. Tailor-made for every customers. 
2. Third-party test for the products you demand. 
3. Test your counter-samples and produce them for you. 
4. Best discount for old customers. 
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. All inquiries will be replied within 12 hours.
10. Dedication to quality, supply & service.
11. Strictly on selecting raw materials.

After-Sale Service

1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods.

The quality control process

1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of products and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before selling 
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.

Process and Advice:
 





Our Advantages

1. Rich experience:Our company is a professional production leading factory in China in pharmaceutical area of many years. 

2. Discreet package :The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also taken into consideration .

3. Top quality. High quality guaranteed, once any problem is found, the package would be reshipped for you .

4. Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.

5. Fast delivery:we have stock, so we can delivery quickly once payment is received.

6. Quality service:we will give you warm after-sale service,if any question we will reply you within 24 hours.

7. Competitive prices:A discount would be given when you make a large order.


Please feel free to contact me if you need any further information~




 




Description

Tenofovir is indicated for the treatment of HIV, HBV infection. This product also can cooperated with other reverse transcriptase inhibitors for HIV-1 infection and hepatitis B treatment.

Pharmacokinetics

Tenofovir is hardly absorbed through the gastrointestinal tract, for this reason, prodrug of Tenofovir has been developed by esterification, and then to make tenofovir fumarate ester. Tenofovir ester is water-soluble, can be rapidly absorbed and degraded into the active tenofovir, and then was metabolized to the active Tenofovir disoproxil. Tenofovir will reach the peak of plasma Concentration within 1-2 h after administration. When combined with food service, the bioavailability of Tenofovir can be increased by 40%. Intracellular half-life of Tenofovir disoproxil is about 10 h, it needs dosing everyday. Because Tenofovir is not a CYP-450 substrate, this may decrease the possibility of interactions with other drugs caused by CYP450. Elimination of Tenofovir is by glomerular filtration and active tubular secretion. Approximately 70% to 80% is recovered in urine as unchanged drug. Elimination half-life is approximately 17 h.

Usage

Acyclic phosphonate nucleotide analogue. Used as an anti-HIV agent
Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.
Tenofovir blocks reverse transcriptase and hepatitis B virus infections.

Adverse effects

1.The most common side effects associated with Tenofovir include asthenia.
2.Tenofovir has also been implicated in mild to moderate gastrointestinal reactions such as nausea, vomiting, diarrhea, and asthenia. Less frequent side effects include hepatotoxicity, abdominal pain, and flatulence,bloating, lactic acidosis, hepatomegaly with fatty liver, pancreatitis and so on. these adverse effects are common with the use of nucleoside analogues either separately or when combined with other drugs.
3.Tenofovir can also lead to metabolic system hypophosphatemia (1% incidence); fat accumulation and redistribution, including central obesity, buffalo hump, peripheral wasting, breast enlargement, Cushing syndrome.
4.Tenofovir may cause lactic acidosis, hepatomegaly with steatosis-related and so on.
5.Tenofovir may make nervous system: dizziness, headache.
6.Tenofovir sometimes leads to respiratory system: dyspnea.
7.Tenofovir may cause skin herpes.



 

Product Packaging

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag),or as required.

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

Storage

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery

Usually within 3-7 working days after payment.

Shipping

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Service

we will try our best to satisfied you.
1. Tailor-made for every customers. 
2. Third-party test for the products you demand. 
3. Test your counter-samples and produce them for you. 
4. Best discount for old customers. 
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. All inquiries will be replied within 12 hours.
10. Dedication to quality, supply & service.
11. Strictly on selecting raw materials.

After-Sale Service

1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods.

The quality control process

1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of products and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before selling 
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.

Process and Advice:
 





Our Advantages

1. Rich experience:Our company is a professional production leading factory in China in pharmaceutical area of many years. 

2. Discreet package :The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also taken into consideration .

3. Top quality. High quality guaranteed, once any problem is found, the package would be reshipped for you .

4. Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.

5. Fast delivery:we have stock, so we can delivery quickly once payment is received.

6. Quality service:we will give you warm after-sale service,if any question we will reply you within 24 hours.

7. Competitive prices:A discount would be given when you make a large order.


Please feel free to contact me if you need any further information~




 

Fat-controling HCA-spirulina tablet is use America material,past international certification. this tablte burning fat effective and no side effect, and it no dependence.

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